Cellular Repair That Starts From Within
If your skin feels thin, crepey, dehydrated or lacking in resilience, polynucleotide therapy offers a regenerative solution that supports repair from within.
Rather than adding volume or temporarily masking concerns, polynucleotides work at a cellular level, stimulating fibroblasts, encouraging collagen production and improving overall skin quality over time.
At HIFU Clinics, polynucleotide treatments are delivered within a clinically led framework, focused on long-term skin health and natural, measurable improvement.
Procedure time
20-40 Minutes
Full recovery
12-48 Hours
Results
1-4 Weeks
Back to work
12-48 Hours
Anaesthetic
Yes
Treatments
2-3
What Are Polynucleotides?
Polynucleotides are highly purified DNA fragments derived from fish sources (commonly salmon or trout), specifically selected for their biocompatibility and regenerative properties.
When carefully injected into the skin, they act as bio-stimulatory molecules that:
- Activate fibroblasts (collagen-producing cells)
- Support tissue repair and regeneration
- Improve skin elasticity and firmness
- Enhance hydration at a deeper level
- Strengthen the extracellular matrix
Unlike dermal fillers, polynucleotides do not create artificial volume. Instead, they improve the structural integrity and function of the skin itself.
How Polynucleotide Therapy Works
Healthy skin depends on a strong extracellular matrix, the supportive network that gives skin its firmness, elasticity and resilience.
As we age, collagen production declines, hydration reduces and inflammatory stress increases. Polynucleotides help by:
- Stimulating collagen and elastin production
- Improving microcirculation
- Supporting skin cell turnover
- Attracting and retaining water in deeper layers
- Reducing oxidative and inflammatory stress
- This makes them particularly effective for thin, fragile, dry or damaged skin.
The result is gradual strengthening and revitalisation rather than immediate but temporary change.
Who Is Polynucleotide Therapy Suitable For?
This treatment is ideal for individuals who:
- Notice thinning or crepey skin
- Struggle with dryness or loss of elasticity
- Want to improve fine lines naturally
- Have sun-damaged or environmentally stressed skin
- Prefer regenerative treatments over volumising injectables
- Are looking to improve delicate areas such as under the eyes or the neck
Polynucleotides are particularly effective for skin quality improvement, rather than reshaping or contouring.
Natural Results That Strengthen Over Time
One of the key benefits of polynucleotide therapy is that results develop gradually and naturally. As collagen and elastin production increase, skin structure improves progressively over several weeks.
Patients often say that polynucleotides help with :
- Softer, smoother texture
- Increased hydration
- Brighter, more radiant appearance
- Improved firmness
- Healthier-looking under-eye area
Because the treatment works with your body’s natural regenerative processes, improvements continue beyond the initial weeks.
Why Choose Polynucleotides at HIFU Clinics?
At HIFU Clinics, regenerative treatments are delivered with precision and anatomical understanding.
Founded by Michelle Clarke, a recognised specialist in collagen-stimulating treatments, our clinic specialises in therapies that support long-term skin structure and function.
Our experience with advanced HIFU and regenerative treatments gives us a deeper understanding of collagen behaviour, tissue response, treatment layering, skin integrity, and so much more.
Polynucleotides are carefully selected and integrated into personalised treatment plans, ensuring they complement, not complicate, your aesthetic goals.
We prioritise:
- CE-marked, clinically approved products
- Careful patient assessment
- Natural-looking outcomes
- Evidence-led treatment protocols
Choose Stronger Skin & Natural Results
If you are looking for a regenerative treatment that improves skin quality without altering your natural features, polynucleotide therapy may be the right choice.
Book a personalised consultation to discuss your concerns and explore whether this collagen-stimulating treatment aligns with your goals. Your safety and long-term skin health are always our priority.
Contact UsFrequently Asked Questions
Polynucleotides are biostimulatory DNA fragments derived from highly purified fish cells. When injected into the skin, they support cellular repair by stimulating fibroblasts, the cells responsible for producing collagen and elastin. This encourages stronger skin structure, improved elasticity and deeper hydration over time.
Polynucleotide therapy can improve a range of concerns, including:
- Fine lines and early signs of ageing
- Loss of firmness and elasticity
- Dehydrated, dull or crepey skin
- Uneven texture and rough patches
- Sun-damaged or environmentally stressed skin
- Fragile under-eye skin
It is most effective for skin quality improvement rather than volumisation or contour change.
A typical session takes 20–40 minutes, depending on the area treated and whether it’s part of a combined protocol. A topical anaesthetic is used to maximise comfort.
Most patients find the treatment comfortable thanks to the topical anaesthetic. You may feel mild pressure or pinprick sensations during injections, but discomfort is usually minimal. Any concerns can be discussed in your consultation.
Results vary by individual, but a course of 2–3 treatments, spaced several weeks apart, is generally recommended for optimal and lasting improvement.
You may notice subtle improvements in hydration and texture within 1–4 weeks. As collagen and elastin stimulation continues, bigger changes, such as improved elasticity and smoother skin, develop over time.
Most people experience minimal downtime. Temporary redness, slight swelling or small injection marks may occur, but these usually resolve within 12–48 hours, allowing you to return to work and social activities quickly.
Yes. Polynucleotide products used in aesthetics are CE-certified medical devices suitable for use in the UK. Because they are highly purified and biocompatible, allergic reactions are rare. Treatments should always be performed by trained clinicians in a clinical setting.
Polynucleotide therapy is suitable for most skin types. At your consultation, we will assess your specific skin condition and discuss whether this treatment aligns with your goals.